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Current Research in Pharmacology and Drug Discovery ...
Current Research in Pharmacology and Drug Discovery (CRPHAR) is a new primary research, gold open access journal from Elsevier. CRPHAR publishes original papers, reviews, graphical reviews, short communications and follow-up manuscripts resulting from research in pharmacology and drug discovery that cover aspects of drug action at the cellular, molecular, and biochemical level.
Clinical Pharmacology 1: Phase 1 studies and early drug ...
Outline the Phase 1 studies conducted to characterize the Clinical Pharmacology of a drug; describe important design elements of and the information gained from
Clinical Pharmacology in Drug Development - Wiley Online ...
The American College of Clinical Pharmacology® invites you to Submit an Abstract for the 2022 ACCP Annual Meeting, "Transforming Global Health through Clinical Pharmacology", Sept 25 - 27, 2022 in Bethesda, MD.
Drug Absorption - Clinical Pharmacology - MSD Manual ...
Drug absorption is determined by the drug’s physicochemical properties, formulation, and route of administration. Dosage forms (eg, tablets, capsules, solutions), consisting of the drug plus other ingredients, are formulated to be given by various routes (eg, oral, buccal, sublingual, rectal, parenteral, topical, inhalational).
Adverse drug reactions | Pharmacology Education Project
Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality. They have historically been classified as either Type A or Type B. Type A ADRs relate to the mechanism of action (i.e. the known pharmacology) of the medication, and are associated with high morbidity and low mortality.
TCMSP: a database of systems pharmacology for drug ...
Background: Modern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little understanding of the underlying mechanisms of action of the herbs. In an effort to promote integration of both sides and to accelerate the drug discovery from herbal medicines, an efficient systems pharmacology platform that represents ideal information convergence of ...
Drug Metabolism - Clinical Pharmacology - MSD Manual ...
Hepatic drug transporters are present throughout parenchymal liver cells and affect a drug’s liver disposition, metabolism, and elimination (for review, see [1, 2 General references The liver is the principal site of drug metabolism (for review, see [1]).Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active—sometimes even more...
Drug distribution | Pharmacology Education Project
The process of transferring a drug from the bloodstream to tissues is referred to as distribution. The same principles that govern drug absorption (e.g. ionization of a drug, lipophilicity of a drug, size of a drug, pH of the environment, etc.) also govern the rate and extent that a drug will distribute to various tissues in the body.
anticancer drug | pharmacology | Britannica
anticancer drug, any drug that is effective in the treatment of malignant, or cancerous, disease. There are several major classes of anticancer drugs; these include alkylating agents, antimetabolites, natural products, and hormones. In addition, there are a number of drugs that do not fall within
Clearance (pharmacology) - Wikipedia
In pharmacology, clearance is a pharmacokinetic measurement of the volume of plasma from which a substance is completely removed per unit time. Usually, clearance is measured in L/h or mL/min. The quantity reflects the rate of drug elimination divided by plasma concentration. Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g ...
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